Studier & Publikationer

Cell and molecular bases. Hernández-Bule ML, Trillo, Martínez-García MA, Abilahoud C, Úbeda A. Chondrogenic Differentiation of Adipose-Derived Stem Cells by Radiofrequency Electric Stimulation. Journal of Stem Cell Research & Therapy. 2017;7(12): 10.


Objective: Although capacitive-resistive electric transfer (CRET) therapies, based on transdermal application of electrothermal radiofrequency currents, have shown promising therapeutic effectiveness in regeneration of traumatic or degenerative tissue lesions, their potential effects on tissues like cartilage, having poor regenerative capabilities, have not been studied sufficiently. Here we investigate the effects of the exposure to a 448 kHz current typically used in CRET therapy, on the early chondrogenic differentiation of human, adipose-derived stem cells (ADSC).


Læs abstract...

Spottorno J, González de Vega C, Buenaventura M, Hernando A. (2017). "Influence of electrodes on the 448 kHz electric currents created by radiofrequency: A finite element study." Electromagn Biol Med 36(3): 306-314.

 

Radiofrequency is a technology used in physical rehabilitation by physicians and physiotherapists for more than fifteen years, although there exist doubts on how it works. Indiba is a particular method that applies a voltage difference of 448 KHz between two electrodes, creating an electric current between them. These electrodes are an active one that is placed on different areas of the body and a passive one that is left on the same position during the treatment. There are two different types of active electrodes: the capacitive one and the resistive one. In this paper, it has been studied how the different electrodes affect the current density inside the body and thus how they affect the efficacy of the treatment. It shows how finite element calculations should help physicians in order to better understand its behavior and improve the treatments.

 

Læs abstract på PubMed...

BIOMEDICAL RESEARCH ON THE INDIBA® SYSTEM AT RAMÓN Y CAJAL HOSPITAL, MADRID. SUMMARY UPDATE SEPTEMBER 2015


Sixteen years of research to further support INDIBA® medical technology that has been and continues to be a benchmark in Rehabilitation Therapy, Beauty and Aesthetic Medicine. This research underpins the valuable contribution of INDIBA® to the health and well-being of our patients.


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Terranova A2, Vermiglio G1, Arena S3, Ciciò A1, di Dio S1, Vermiglio M1. Monopolar capacitive resistive radio-frequency 448 kHz in the post surgical treatment of femoral fracture. Eur Med Phys. 2008; 44 (Suppl 1)(3):1-2

Objective:

To evaluate the effects of INDIBA® Monopolar Capacitive Resistive Radio-Frequency device at 448 kHz
in the treatment of pain and oedema in patients with a femoral fracture who have undergone surgery with osteosynthesis, endoprosthesis or arthroprosthesis

 

Material and Methods:

30 patients with an average age of 75 years old divided into two groups, the first group treated with INDIBA®together with the normal protocol of rehabilitation. The second group (control) was treated with the standard protocol for rehabilitation. Pain and muscle oedematous infiltration were evaluated.

 

Results:

Pain showed a significant increase in both groups during the first day after surgery. The treated group with INDIBA® showed a statistically significant reduction of pain during the 4th (p=0.0045) and the 7th (p=0.033) day. In the control group there was no significant pain reduction (table 1). Oedema increase in the perimeter of thigh of both groups until the 4th day reached values of 1 cm in the INDIBA® group and 1.8 cm in the control group. The 0.8 cm difference between both groups showed a statically significant difference (p=0.009). Later these values have been reduced in a non statistically significant way in both groups until they reach a similar value in the thirtieth day (graphic 1).

 

Conclusions:

  • Monopolar Capacitive Resistive Radio-Frequency device at 448 kHz significantly reduces pain and oedema during the first days after surgery.
  • Results can be explained by means of a non-thermal application since the first day of surgery, this has a positive effect on lymph and arterial microcirculation, which apparently are the basis of these good results.

Læs abstract...

Hernández-Bule ML, Martinez-Botas J, Trillo MA, Paino CL, Ubeda A. Antiadipogenic Effects of Subthermal Electric Stimulation at 448 Khz on Differentiating Human Mesenchymal Stem Cells. Mol Med Rep,2016; 13, (5): 3895-903.

 

The 448 kHz capacitiveresistive electric transfer (CRET) is an electrothermal therapy currently applied in anticellulite and antiobesity treatments. The aim of the present study was to determine whether exposure to the CRET electric signal at subthermal doses affected early adipogenic processes in adiposederived stem cells (ADSC) from human donors. ADSC were incubated for 2 or 9 days in the presence of adipogenic medium, and exposed or shamexposed to 5 min pulses of 448 kHz electric signal at 50 microA/mm2 during the last 48 h of the incubation. Colorimetric, immunofluorescence, western blotting and reverse transcriptionquantitative polymerase chain reaction assays were performed to assess adipogenic differentiation of the ADSC. Electric stimulation significantly decreased cytoplasmic lipid content, after both 2 and 9 days of differentiation.

 

The antiadipogenic response in the 9 day samples was accompanied by activation of mitogenactivated protein kinase kinase 1/2, decreased expression and partial inactivation of peroxisome proliferatoractivated receptor (PPAR) gamma, which was translocated from the nucleus to the cytoplasm, together with a significant decrease in the expression levels of the PPARG1 gene, perilipin, angiopoietinlike protein 4 and fatty acid synthase. These results demonstrated that subthermal stimulation with CRET interferes with the early adipogenic differentiation in ADSC, indicating that the electric stimulus itself can modulate processes controlling the synthesis and mobilization of fat, even in the absence of the concomitant thermal and mechanical components of the thermoelectric therapy CRET.

 

Læs abstract på PubMed...

Hernández-Bule ML, Paino CL, Trillo MA, Ubeda A. Electric Stimulation at 448 Khz Promotes Proliferation of Human Mesenchymal Stem Cells. Cell Physiol Biochem. 2014;34(5): 1741-55.


BACKGROUND/AIMS:

Capacitive-resistive electric transfer (CRET) is a non invasive electrothermal therapy that applies electric currents within the 400 kHz - 450 kHz frequency range to the treatment of musculoskeletal lesions. Evidence exists that electric currents and electric or magnetic fields can influence proliferative and/or differentiating processes involved in tissue regeneration. This work investigates proliferative responses potentially underlying CRET effects on tissue repair. METHODS: XTT assay, flow cytometry, immunofluorescence and Western Blot analyses were conducted to asses viability, proliferation and differentiation of adipose-derived stem cells (ADSC) from healthy donors, after short, repeated (5 m On/4 h Off) in vitro stimulation with a 448-kHz electric signal currently used in CRET therapy, applied at a subthermal dose of 50 muA/mm(2)

 

RESULTS:

The treatment induced PCNA and ERK1/2 upregulation, together with significant increases in the fractions of ADSC undergoing cycle phases S, G2 and M, and enhanced cell proliferation rate. This proliferative effect did not compromise the multipotential ability of ADSC for subsequent adipogenic, chondrogenic or osteogenic differentiation.

 

CONCLUSIONS:

These data identify cellular and molecular phenomena potentially underlying the response to CRET and indicate that CRET-induced lesion repair could be mediated by stimulation of the proliferation of stem cells present in the injured tissues.

 

Læs abstract...

Kato, S., et al. (2013). "Repressive effects of a capacitive-resistive electric transfer (CRet) hyperthermic apparatus combined with provitamin C on intracellular lipid-droplets formation in adipocytes." Int J Hyperthermia 29(1): 30-37.

PURPOSE:

The aim of this study was to evaluate inhibitory effects of L-ascorbic acid-2-O-phosphate-Na(2) (APS), a pro-vitamin C, combined with hyperthermia on adipogenic differentiation of mouse stromal cells, OP9.

 

MATERIALS AND METHODS:

OP9 preadipocytes were differentiated with serum replacement, administered with APS, and simultaneously treated with hyperthermia using a capacitive-resistive electric transfer (CRet) apparatus, which was conducted repeatedly twice a day. After 2 days, intracellular lipid droplets were stained with Oil Red O, then observed by microscopy and assessed spectrophotometrically.

 

RESULTS:

After stimulation by serum replacement for 2 days, lipid droplets were accumulated surrounding nucleus of OP9 cells. When APS of 0.15-0.6 mM was administered without hyperthermia, the amount of lipid droplets was markedly suppressed to 50.5% approximately -11.3% versus the undifferentiated control, and diminished huge aggregates of lipid droplets. In OP9 cells treated by hyperthermia at 42 degrees C for 0.5 min, 1 min or 3 min in the absence of APS, adipogenesis was suppressed abruptly in a time-dependent manner to 95.4%, 18.7% or -5.5%, respectively. Whereas, the percentage of adipogenesis was 96.8% in OP9 cells treated by mild hyperthermia alone at 41 degrees C for 1 min. The simultaneous application of APS and hyperthermia at 41 degrees C for 1 min markedly suppressed the accumulation of lipid droplets to 25.7% approximately -66.2%. By scanning electron microscopy (SEM) observation, the surface of OP9 cells treated with APS and hyperthermia appeared to have the morphological property of undifferentiated OP9 cells.

 

CONCLUSION:

Combined treatment of APS and mild hyperthermia suppresses adipogenesis in OP9 cells, particularly in lipid droplets accumulation during spontaneous differentiation of OP9 preadipocytes.

 

Læs abstract på PubMed...

Yokota Y, Sonoda T, Tashiro Y, Suzuki Y, Kajiwara Y, Zeidan H, et al. Effect of Capacitive and Resistive electric transfer on changes in muscle flexibility and lumbopelvic alignment after fatiguing exercise. Journal of physical therapy science. 2018;30(5):719-25.

Purpose:

This study aimed to clarify the effects of Capacitive and Resistive electric transfer (CRet) on changes in muscle flexibility and lumbopelvic alignment after fatiguing exercise.

 

Subjects and Methods:

Twenty-two healthy males were assigned into either the CRet (n=11) or control (n=11) group. Fatiguing exercise and CRet intervention were applied at the
quadriceps muscle of the participants' dominant legs.

The Ely test, pelvic tilt, lumbar lordosis, and superficial temperature were measured before and after exercise and for 30 minutes after intervention. Statistical analysis was performed using one-way analysis of variance, with Tukey's post-hoc multiple comparison test to clarify within-group changes and Student's t-test to clarify between-group differences.

 

Results:

The Ely test and pelvic tilt were significantly different in both groups after exercise, but there was no difference in the CRet group after intervention. Superficial temperature significantly increased in the CRet group for 30 minutes after intervention, in contrast to after the exercise and intervention in the control group. There was no significant between-group difference at any timepoint, except in superficial temperature.

 

Conclusion:

CRET could effectively improve muscle flexibility and lumbopelvic alignment after fatiguing exercise.


Læs abstract på PubMed...

Kumaran B, Watson T. Skin Thermophysiological Effects of 448 Khz Capacitive Resistive Monopolar Radiofrequency in Healthy Adults: A Randomised Crossover Study and Comparison with Pulsed Shortwave Therapy. Electromagn Biol Med. 2018: 1-12.

Radiofrequency-based electrophysical agents (EPA) have been used in therapy practice over several decades (e.g., shortwave therapies). Currently, there is insufficient evidence supporting such devices operating below shortwave frequencies.

This laboratory-based study investigated the skin physiological effects of 448 kHz capacitive resistive monopolar radiofrequency (CRMRF) and compared them to pulsed shortwave therapy (PSWT).

 

In a randomised crossover study, seventeen healthy volunteers received four treatment conditions - High, Low and Placebo dose conditions receiving 15-min CRMRF treatment and a Control condition receiving no intervention. Fifteen participants also received high dose PSWT for comparison. Treatment was applied to the right lower medial thigh. Pre, post and 20-min follow-up measurements of skin temperature (SKT), skin blood flow (SBF) and nerve conduction velocity (NCV) were obtained using Biopac MP150 system. Group data were compared using the ANOVA model. Statistical significance was set at p

 

Overall, the CRMRF physiological responses were significantly more pronounced than that of PSWT. No significant changes in NCV were noted for any condition. Physiological changes associated with CRMRF were more pronounced when compared to PSWT, placebo or control. Any potential stronger therapeutic benefits of CRMRF need to be confirmed by comparative clinical studies.

 

Læs abstract på PubMed...

Tashiro Y, Hasegawa S, Yokota Y, Nishiguchi S, Fukutani N, Shirooka H, Tasaka S, Matsushita T, Matsubara K, Nakayama Y, Sonoda T, Tsuboyama T, Aoyama T. Effect of Capacitive and Resistive Electric Transfer on Haemoglobin Saturation and Tissue Temperature. Int J Hyperthermia. 2017: 1-7.


PURPOSE:

This study aims to evaluate the effects of Capacitive and Resistive electric transfer (CRet) and hotpack (HP) on haemoglobin saturation and tissue temperature.

 

MATERIALS AND METHODS:

The participants were 13 healthy males (mean age 24.5 +/- 3.0). They underwent three interventions on different days: (1) CRet (CRet group), (2) HP (HP group) and (3) CRet without power (sham group). The intervention and measurement were applied at the lower paraspinal muscle. Indiba(R) active ProRecovery HCR902 was used in the CRet group, and the moist heat method was used in the HP group. Oxygenated, deoxygenated and total haemoglobin (oxy-Hb, deoxy-Hb, total-Hb) counts were measured before and after the 15-min interventions, together with the temperature at the skin surface, and at depths of 10 mm and 20 mm (ST, 10mmDT and 20mmDT, respectively). The haemoglobin saturation and tissue temperature were measured until 30 min after the intervention and were collected at 5-min intervals. Statistical analysis was performed for each index by using the Mann-Whitney U test for comparisons between all groups at each time point.

 

RESULTS:

Total-Hb and oxy-Hb were significantly higher in the CRet group than in the HP group continuously for 30 min after the intervention. The 10mmDT and 20mmDT were significantly higher in the CRet group than in the HP group from 10- to 30 min after intervention.

 

CONCLUSIONS:

The effect on haemoglobin saturation was higher in the CRet group than in the HP group. In addition, the CRet intervention warmed deep tissue more effectively than HP intervention.

 

Læs abstract på PubMed...

Yokota Y, Tashiro Y, Suzuki Y, Tasaka S, Matsushita T, Matsubara K, Kawagoe M, Sonoda T, Nakayama Y, Hasegawa S, Aoyama T. Effect of Capacitive and Resistive Electric Transfer on Tissue Temperature, Muscle Flexibility, and Blood Circulation. J Nov Physiother. 2017;07(01).

Introduction:

The differences between Capacitive and Resistive electric transfer (CRet) and hot pack (HP) in their effects on tissue temperature, muscle flexibility, and blood circulation are unknown. This study aimed to clarify the effect of CRet and HP on tissue temperature, muscle flexibility, and blood circulation.

Methods:

The participants were 13 healthy adults. They randomly performed three 15-minute interventions: (1) CRet, (2) HP, and (3) without powered CRet (sham). The intervention and measurement were applied to the right hamstring muscle. INDIBA® activ ProRecovery HCR902 was used in the CRet trial. The moist heat method was used in the HP trial. The measurement indexes were superficial temperature (ST), 10-mm deep temperature (DT), and 20-mm DT; the passive straight leg raise (SLR) test; and oxygenated (oxy), deoxygenated (deoxy), and total (total) hemoglobin (Hb) concentrations. Each index was measured for 30 minutes after the intervention and the amount of change (?) from the pre-intervention value was calculated.

Results:

?ST, ?10 mmDT, ?20 mmDT, ?oxy-Hb, and ?total-Hb were significantly higher in the CRet and HP trials than in the sham trial for 30 minutes after the intervention (p<0.05). ?SLR was significantly higher in the CRet trial than in the HP trial from 15 to 30 minutes after the intervention (p<0.01)

Conclusion:

Our results indicate that CRet is an efficient method for preventing and treating musculoskeletal injuries and improve muscle flexibility. In addition, it can improve blood circulation as well as HP can.

Kumaran B, Herbland A, Watson T. Continuous-Mode 448 Khz Capacitive Resistive Monopolar Radiofrequency Induces Greater Deep Blood Flow Changes Compared to Pulsed Mode Shortwave: A Crossover Study in Healthy Adults. European Journal of Physiotherapy. 2017;19(3): 137-46.

Aims:

Radiofrequency-based electrophysical agents (EPAs) have been used in therapy practice over several decades (e.g. shortwave therapies). Currently, there is insufficient evidence supporting such EPAs operating below shortwave frequencies. This laboratory-based study investigated the deep physiological effects of 448kHz capacitive resistive monopolar
radiofrequency (CRMRF) and compared them to pulsed shortwave therapy (PSWT).

 

Methods:

In a randomized crossover study, 17 healthy volunteers initially received four treatment conditions: high, low and placebo dose conditions receiving 15-min CRMRF treatment and a control condition receiving no intervention. Fifteen participants additionally received high-dose PSWT as fifth condition, for comparison. Pre- and post-treatment measurements of deep blood flow and tissue extensibility were obtained using Doppler ultrasound and sonoelastography. Group data were compared using analysis of variance model. Statistical significance was set at p.05, 0.8 power, and 95% confidence interval.

 

Results:

Significant increases in volume and intensity of deep blood flow were obtained with CRMRF over placebo, control (p¼.003) and PSWT (p<.001). No significant changes in blood flow velocity or tissue extensibility were noted for any condition.

 

Conclusions:

Deep blood flow changes with CRMRF were more pronounced than that with PSWT, placebo or control. Potential greater therapeutic benefits need to be confirmed with comparative clinical studies.

 

Læs full text...

Kumaran B, Watson T. Thermal build-up, decay and retention responses to local therapeutic application of 448 kHz capacitive resistive monopolar radiofrequency: A prospective randomised crossover study in healthy adults. Int J Hyperthermia. 2015; 31(8): 883-895.

 

PURPOSE:

Radiofrequency-based electrophysical agents are widely used in therapy-related clinical practice for their thermal effects, mainly relieving pain and inflammation and improving tissue extensibility. The most commonly used and researched are shortwave therapies that operate at 27.12 MHz. Although relatively new, electrophysical agents employing much lower frequencies have also emerged. Capacitive resistive monopolar radiofrequency employing 448 kHz is one such therapy. This laboratory-based study was aimed to investigate the skin thermal responses to 448 kHz radiofrequency-based therapy in healthy adults.

 

METHODS:

In a two-group randomised crossover study, 15 volunteers attended two modes (capacitive and resistive) of 448 kHz radiofrequency-based therapy (using 'Indiba Activ 902') administered locally to the lower thigh region. Starting at minimum, the intensity was increased incrementally until thermal discomfort was felt. Participants reported three time points: thermal onset, definite thermal sensation, and onset of thermal discomfort. Local skin temperature was measured before, immediately post-treatment and up to 45 min post-treatment.

 

RESULTS:

Both capacitive and resistive modes of therapy significantly increased the skin temperature and sustained it over the 45-min follow-up. There was statistically significant difference between the thermal response patterns produced by the two modes. Peak post-treatment temperatures attained were not significantly different between the two; however, the retention rate at follow-up was significantly higher for the resistive mode.

 

CONCLUSIONS:

This study confirms that radiofrequency-based therapy at 448 kHz can significantly increase and sustain skin temperature. The study also provides useful baseline data for further research in the low frequency ranges of radiofrequency-based therapy that remain largely unexplored.

 

Læs abstract på PubMed...

Naranjo P, López Andrino R, Pinto H. First Assessment of the Proionic Effects Resulting from Non-Thermal Application of 448 Khz Monopolar Radiofrequency for Reduction of Edema Caused by Fractional CO2 Laser Facial Rejuvenation Treatments. Journal of Surgery. 2015:3(1): 21.

Among the side effects which occur after treatment with fractional CO2 laser, one of the most frequent and incapacitating is temporary edema, which is functionally and esthetically incompatible with the patient going immediately back to their social and work life. The 448 kHz capacitive/resistive monopolar radiofrequency proionic systemis based on the subthermal electrical stimulation of biological tissues, enabling the restoration of physiological membrane potentials, as well as the ionic balance established through the membrane. This system is capable of improving membrane permeability for an adequate maintenance of cell functions, as well as improving circulation and reducing fluid retention.This study involved one application before laser treatment and one application 24 hours after laser treatment.

 

The results of skin ultrasound presented in this study show that proionic effects help restrict edema progression, thereby reducing recovery time.

Naranjo P, López R, Pinto H. Reduction of erythema after laser on rosacea by subthermal 448 khz monopolar radiofrequency. IJDR. 2015;5(3): 3775-3777.

Excellent results are usually obtained when facial benign vascular alterations such as erythrosis and couperosis are treated with vascular laser (pulsed dye, KTP, Neodimiun-YAG) or with Intense Pulsed Light (IPL). However, the erythema occurring at hours or days after such treatment may hamper the patients’ ability to go back to their daily lives and increase the risk of adverse effects. The 448 kHz capacitive/resistive monopolar radiofrequency system is based on the subthermal electrical stimulation of tissues, enabling the restoration of ionic balance at cell level. For this study, this system was applied on patients with erythematotelangiectatic rosacea before and immediately after treatment with pulsed dye laser.

This technology helps restrict the progression of treatment-related erythema, thereby reducing recovery time and the risk of more serious adverse effects.

Yupakorn K, Amornvittayachan O, Udompataikul M. Efficacy of Monopolar Radiofrequency Device on Cellulite Treatment. Srinagarind. Med J. 2010;25(4): 258-64.

Background and objective:

The treatment of cellulite has not been standardized. The aim of this study is to evaluate the efficacy of the 0.5 MHz monopolar radiofrequency device on cellulite treatment.

 

Methods:

Twenty-one volunteers were enrolled and received the treatment with monopolar radiofrequency device, 50 minutes for their thighs and 40 minutes for their buttocks. The number of treatment was 10 sessions in total. The volunteers’ weight and circumference of buttocks and thighs were recorded. The thickness of subcutaneous tissue of both regions was also evaluated by ultrasound at the end of treatment and at 4 weeks after the final treatment. The clinical evaluation of cellulite improvement was assessed by photograph grading.

 

Results:

The volunteers had significantly lost their weight (P = 0.002). The average circumference reduction of buttocks and thighs on the last treatment were 1.60 cm and 1.67 cm, respectively (P < 0.001, P < 0.001). The reduction of the thickness of superficial layer of subcutaneous tissue of buttocks and thighs was 2.63 mm and 1.56 mm, respectively (P = 0.004, P < 0.001). The average circumference reduction of buttocks and thighs were 1.75 cm and 1.84 cm, respectively at 4 weeks after the final treatment (P < 0.001, P < 0.001). The reduction of the thickness of superficial layer of subcutaneous tissue of buttocks and thighs was 3.31 mm and 2.37 mm, respectively (P < 0.001, P < 0.001). The clinical evaluation of cellulite demonstrated that most of the volunteers (85.7%) had clinical improvement.

 

Conclusion:

0.5 MHz monopolar radiofrequency can be considered as an alternative choice of cellulite treatment. Keywords: cellulite, circumference reduction, monopolar radiofrequency device.

Fernández-Galiano B, Gómez-Domínguez S. Structural changes in recalcitrant epitrochlear tendinopathy after the combined application of percutaneous needle electrolisys, PRP and active biological stimulus in a professional tennis player. J Invasive Tech Phys Ther. 2016;1(2):2.

Introduction/aims:

Epitrochlear tendinopathy is a degenerative pathology of the common epitrochlear tendon, which courses with pain at the medial elbow and functional impairment. In advanced stages, it incapacitates athletes and compromises activities of daily living. The aim of the present communication was to describe the case of a professional tennis player with chronic epitrochlear tendinopathy treated with percutaneous needle electrolysis, PRP and active biological stimulus. Patient and methods: A male, professional tennis player, aged 34 years old, with a left epitrochlear tendinopathy of 7-months evolution, was forced to interrupt his sports activity due to functional impairment secondary to the injury. Imaging tests (NMR and ultrasound) confirmed the presence of an epitrochlear tendinosis with intrasubstance rupture of the epitrochlear tendon. The patient received 2 infiltrations of Celestone + Scandinibsa in the 5 months prior to receiving treatment. A conservative, minimally invasive treatment was programmed, lasting 8 weeks, in which invasive physiotherapy techniques were combined with active loading exercises, with the therapeutic aim of restoring the functionality of the tendon, avoiding surgery, readapting it to support the loads required in professional tennis. A physiotherapist external to this process performed an initial and final assessment of the case. The invasive physiotherapy interventions were performed by a second physiotherapist, whereas the active readaptation work was planned and supervised by a third physiotherapist. The material used was: GE Logiq S7 and S8 ultrasound machine, Indiba Activ 902, Physio Invasiva® , Kit Orthopass 20 ml by Proteal, Agu-punt needles measuring 25 mm, and the sports installations of the Chamartín Tennis Club.

 

Results:

The ultrasound examination on behalf of the physiotherapist who was blinded to the treatment process revealed structural changes in the tendon, with an absence of neovascularization and an increased resistance of the tissue, evaluated using elastography. At the same time, the patient’s symptoms subsided and his functionality improved.

 

Conclusions:

After 8 weeks of treatment, and considering the structural changes that were visible in the ultrasound images, we can conclude that the combination of PNE + PRP + active biological stimulus is an effective treatment option for cases of recalcitrant epitrochlear tendinopathy. The patient’s functionality is optimal, returning to training periods prior to competition.

Bito T, Tashiro Y, Suzuki Y, Kajiwara Y, Zeidan H, Kawagoe M, et al. Acute Effects of Capacitive and Resistive electric transfer on the Achilles tendon. Electromagnetic Biology and Medicine. 2018.

 

This study aimed to investigate the acute effects of capacitive and resistive electric transfer (CRet) on Achilles tendon elongation during muscle contraction, as well as the circulation in the peritendinous region.

 

Sixteen healthy men participated in this study. All 16 participants underwent 2 interventions: (1) CRet trial and (2) CRet without power (sham trial). Tendon elongation was measured four times. Using near-infrared spectroscopy, the blood circulation (volume of total-hemoglobin (Hb), oxygenated hemoglobin (oxy-Hb), and deoxygenated hemoglobin (deoxy-Hb)) was measured for 5 min before the intervention and for 30 min after the intervention. The differences between the measurements obtained before and after intervention were compared between the two interventions. The changes in tendon elongation and deoxy-Hb were not significantly different between the interventions. Total- and oxy-Hb were significantly increased in the CRet trial compared with the sham trial. In addition, the increases in total-Hb and oxy-Hb lasted for 30 min after the CRet intervention (CRet vs. sham: oxy-Hb: F = 8.063, p = 0.001, total-Hb: F = 4.564, p = 0.011).

 

In conclusion, CRet significantly improved blood circulation in the peritendinous region.

Takahashi K, Suyama T, Onodera M, Hirabayashi S, Tsuzuki N, Zhong-Shi L. Clinical Effects of Capacitive Electric Transfer Hyperthermia Therapy for Lumbago. J. Phys. Ther. Sci. 1999;11: 45-51.

We conducted physical therapy for patients suffering from lumbago (n=37) with highfrequency hyperthermia equipment by a capacitive electric transfer method, MD-303 (0.65 ± 0.05 MHz), which is employed in Europe and America. The 37 patients comprised 13 with lumbar spondylosis deformans, 7 with lumbar spinal canal stenosis, 5 with lumbar disc herniation, 4 with lumbar spondylolysis/spondylolisthesis, 4 with lumbar discopathy, and 4 with other diseases accompanied by lumbago. The electricity was used 10 times in total, for 20 minutes per time.

 

Result:

A rise in skin temperature was observed even 15 minutes after treatment, with no occurrence of adverse reactions, and this therapy was highly effective in relieving pain, with an efficacy rate of 81.1%. This paper reports the results of the use of this therapy.

Takahashi K, Suyama T, Onodera M, Hirabayashi S, Tsuzuki N, Zhong-Shi L. Clinical Effects of Capacitive Electric Transfer Hyperthermia Therapy for Cervico-Omo-Brachial Pain. J. Phys. Ther. Sci. 2000;12: 43-48.

We conducted physical therapy for patients suffering from cervico-omo-brachial pain (n=22) with high frequency hyperthermia equipment by a capacitive electric transfer method, MD-303 (0.65 ± 0.05 MHz), which is employed in Europe and America. The 22 patients comprised 6 with cervical spondylosis deformans, 6 with cervico-omo-brachial pain syndrome, 4 with periarthritis scapulohumeralis, 3 with cervical sprain, 2 with tennis elbow, and 1 with RA hand. The electrotherapy was performed 10 times in total, for 20 min per time.

 

Result:

A rise in skin temperature was observed even 15 min after treatment, with no occurrence of adverse reactions, and this therapy was highly effective in relieving pain, with an efficacy rate of 81.8%. This paper reports the results of the use of this therapy. Key words: Cervico-omo-brachial pain, Physical therapy, Capacitive electric transfer.

Kumaran B, Watson T. Treatment using 448kHz capacitive resistive monopolar radiofrequency improves pain and function in patients with osteoarthritis of the knee joint: a randomised controlled trial. Physiotherapy. 2019;105(1):98-107.

OBJECTIVE:

This study investigated whether capacitive resistive monopolar radiofrequency (CRMRF)-based treatment improves pain and function among patients with osteoarthritis of the knee. DESIGN AND SETTING: Three-group randomised controlled trial with concealed allocation, participant blinding and intention-to-treat analysis. Forty-five patients diagnosed with osteoarthritis, from the waiting list for physiotherapy at a local hospital were enrolled.

 

INTERVENTION:

Participants in the active and sham groups received eight sessions of CRMRF and sham-CRMRF respectively over four weeks, along with standard care. The control group received standard care only.

 

ASSESSMENT:

Pain and function were measured at four time points: week zero (baseline), week four (post intervention), week eight and week 16 (two follow-ups) using visual analogue scale (VAS), Western Ontario and McMaster Universities (WOMAC) Osteoarthritis Index, timed up and go (TUG) test and knee range of motion (ROM).

 

RESULTS:

For pain (VAS), there were clinically significant changes in the active group at post treatment compared to sham (Mean difference: 0.79 (95% CI: 0.29 to 1.3), effect size: 1.3) and control (Mean difference: 0.82 (95% CI: 0.32 to 1.3), effect size: 1.5), and at one-month follow-up compared to control (Mean difference: 0.68 (95% CI: 0.10 to 1.3), effect size: 1.1). For function (WOMAC), there was clinically significant change in the active group at post treatment compared to control (Mean difference: 1.3 (95% CI: 0.02 to 2.6), effect size: 0.94), but not compared to sham. No meaningful differences were noted for TUG or knee ROM. No differences were noted at three-month follow-up for any outcomes.

 

CONCLUSION:

CRMRF treatment can improve pain and function in patients with knee osteoarthritis in the short term. TRIAL REGISTRATION: NIHR-CRN study ID: 20264.

Pavone C, Castrianni D, Romeo S, Napoli E, Usala M, Gambino G, et al. TECAR therapy for Peyronie's disease: a phase-one prospective study. Great evidence in patients with erectile dysfunction. Urologia. 2013;80(2):148-53.

Our phase-one prospective study wants to evaluate the safety and tolerability of TECAR therapy in the treatment of Peyronie's disease. From June 2011 to September 2012 we enrolled 70 patients. Each patient had been previously subjected to andrological examination, to a questionnaire for the evaluation of IPP and ED, and the SF-36 (V1) for the evaluation of the general state of health. The evaluation of pain was made using the VAS scale of pain. Every patient was subjected to TECAR treatment of the fibrotic plaque (both in resistive mode and in capacitive mode) for a total of three sessions carried out on consecutive days. We recorded a good compliance by patients; none of them reported side effects. Pain was decreased by the technique in 80% of the cases.The whole sample completed the study. Surprisingly enough those patients who complained also of erectile dysfunction, reported an improvement in sexual potency.


Læs abstract på PubMed...

Oh MM, Jin MH, Moon DG, Nam SG, Bae JH, Park SH. A Prospective, Randomized, Placebo Controlled Study of Radiofrequency Therapy for the Treatment of Chronic Prostatitis/Chronic Pelvic Pain Syndrome. J Urol. 2009; Vol. 181(4), Supplement, Sunday): 122.

INTRODUCTION AND OBJECTIVE:

Male chronic prostatitis/ chronic pelvic pain syndrome (CPPS) is a condition of uncertain etiology and treatment is often unsatisfactory. There is evidence that the symptom complex may result from pelvic floor muscular dysfunction and/or neural hypersensitivity/inflammation. We evaluated that the application of radiofrequency therapy may have a therapeutic effect on chronic prostatitis/chronic pelvic pain syndrome.

 

METHODS:

Thirty men with chronic prostatitis/chronic pelvic pain syndrome CPPS (inflammatory or non-inflammatory) for 6 months, and who had failed to improve with standard antibiotic therapy, were prospectively randomized to receive radio-frequency or placebo therapy. Radiofrequency therapy consisted of 30 minutes of pelvic floor stimulation at a frequency of 0.5MHz, twice weekly for 4 weeks. Patients were evaluated at baseline, 1 month after treatment using validated NIH-chronic prostatitis symptom index (NIH-CPSI) and pelvic pain symptom survey (PPSS).

 

RESULTS:

A total of 30 men with a mean age of 46.3 years (range 23 to 72) were analyzed. Of the 30 men 20 were randomized to the active treatment group and 10 were randomized to the placebo treatment group. Mean symptom scores decreased significantly in the actively treated group at 1 months (p<0.05), unlike the placebo group, which showed no significant change (p>0.05). Subanalysis of those receiving active treatment showed that the greatest improvement was in pain related symptoms.

 

CONCLUSIONS:

The novel use of pelvic floor radiofrequency therapy may be a promising new noninvasive option for chronic prostatitis/ CPPS in men.

Fernández Carnero J, Serra Llosa L, Llanes González L. MONOPOLAR RADIOFREQUENCY CAPACITIVE RESISTIVE AT 448 kHz (INDIBA® SYSTEM) FOR THE TREATMENT OF CHRONIC PELVIC PAIN OF INFLAMMATORY ORIGIN


Introduction:

Pelvic floor is a complex anatomical structure formed by muscles, fasciae and ligaments. Its main function includes: supporting the abdominal floor, hold the vesical anatomical structure of the pelvis (urethra, vagina, bladder, rectum and uterus), urinary and fecal containment and maintain the vaginal tone, so the feminine sexuality as well (1, 2). Age, childbirth and lifestyle can affect the appearance of disorders such as pelvic pain, urinary and fecal incontinence, dyspareunia or vaginismus (3). As a whole, pelvic fl oor disorders have a high prevalence, being estimated that a third of the female population is affected by them (4, 5). The treatment of the main part of pelvic fl oor pathologies needs a multidisciplinary approach that includes, among others, radiofrequency (RF) (1, 5, 6). The present work is the clinical investigation to assess the effi cacy and safety of INDIBA® 448 kHz RF device to treat chronic pelvic pain of infl ammatory origin through intracavitary treatmens.

 

Objectives:

The primary objective was to evaluate the effectiveness (at short and midterm) of manual therapy in combination with an intracavitary application of INDIBA® 448 kHz RF device (vagina/rectum) to treat chronic pelvic pain of infl ammatory origin. To assess this objective the following variables were taken into account:

  • Change of pain intensity using the visual analogue scale (VAS), and considering the change from the basal visit to the 10-S visit.
  • Change in the chronic pelvic pain questioner of Mohedo (CPPQ-Mohedo).
  • Change in the Depression and Anxiety Scale of Goldberg.
  • Change in the National Institute of Health Chronic Prostatitis Symptoms Index (NIH-CPSI), only for male patients.
  • Infl ammatory clinical variables evaluated the professional staff.
  • Global fi nal evaluation by the patients and by the professional staff.

The second objective was to evaluate its safety and tolerability.

 

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